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A chancre (/ˈʃæŋkər/ SHANG-kər) is a painless genital ulcer most commonly formed during the primary stage of syphilis. This infectious lesion forms approximately 21 days after the initial exposure to Treponema pallidum, the gram-negative spirochaete bacterium yielding syphilis.‎Similarities with chancroid · ‎Differences from chancroid. Feb 3, - Primary stage syphilis sore (chancre) on the surface of a tongue. Secondary stage syphilis sores (lesions) on the palms of the hands.